Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis

Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis. COX-2 inhibitors, which block the formation of prostaglandins, su...

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Bibliographic Details
Main Authors: Zhang, Guodong, Panigrahy, Dipak, Hwang, Sung Hee, Yang, Jun, Mahakian, Lisa M., Wettersten, Hiromi I., Liu, Jun-Yan, Wang, Yanru, Ingham, Elizabeth S., Tam, Sarah, Kieran, Mark W., Weiss, Robert H., Ferrara, Katherine W., Hammock, Bruce D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121808/
https://ncbi.nlm.nih.gov/pubmed/25024195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410432111
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