Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

Adipose tissue expansion during obesity is associated with increased macrophage infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. Identification of the major factors that mediate detrimental effects of...

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Bibliographic Details
Main Authors: Gao, Dan, Madi, Mohamed, Ding, Cherlyn, Fok, Matthew, Steele, Thomas, Ford, Christopher, Hunter, Leif, Bing, Chen
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121578/
https://ncbi.nlm.nih.gov/pubmed/24918199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00430.2013
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