Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways

Allergic rhinitis is a chronic inflammatory disease orchestrated by Th2 lymphocytes. Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 is known to be a negative regulator in the IL-4α/STAT-6 signaling pathway of the lung. However, the role of SHP-1 enzyme and its functional relat...

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Main Authors: Cho, Seok Hyun, Oh, Sun Young, Lane, Andrew P., Lee, Joan, Oh, Min-Hee, Lee, Seakwoo, Zheng, Tao, Zhu, Zhou
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121172/
https://ncbi.nlm.nih.gov/pubmed/25090641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103685
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