Engineering of Bispecific Affinity Proteins with High Affinity for ERBB2 and Adaptable Binding to Albumin

The epidermal growth factor receptor 2, ERBB2, is a well-validated target for cancer diagnostics and therapy. Recent studies suggest that the over-expression of this receptor in various cancers might also be exploited for antibody-based payload delivery, e.g. antibody drug conjugates. In such strate...

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Bibliographic Details
Main Authors: Nilvebrant, Johan, Åstrand, Mikael, Georgieva-Kotseva, Maria, Björnmalm, Mattias, Löfblom, John, Hober, Sophia
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121139/
https://ncbi.nlm.nih.gov/pubmed/25089830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103094
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