Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

BACKGROUND: Oncogenic mutational analysis provides predictive guidance for therapeutics such as anti-EGFR antibodies, but it is successful only for a subset of colorectal cancer (CRC) patients. METHOD: A comprehensive molecular profiling of 120 CRC patients, including 116 primary, 15 liver metastasi...

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Detalhes bibliográficos
Main Authors: Lee, Jeeyun, Jain, Anjali, Kim, Phillip, Lee, Tani, Kuller, Anne, Princen, Fred, In-Gu, Kim, Suk Hyeong, Park, Joon Oh, Park, Young Suk, Singh, Sharat, Kim, Hee Cheol
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121133/
https://ncbi.nlm.nih.gov/pubmed/25090459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103551
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