Multi-Agent Chemotherapy Overcomes Glucocorticoid Resistance Conferred by a BIM Deletion Polymorphism in Pediatric Acute Lymphoblastic Leukemia

A broad range of anti-cancer agents, including glucocorticoids (GCs) and tyrosine kinase inhibitors (TKIs), kill cells by upregulating the pro-apoptotic BCL2 family member, BIM. A common germline deletion in the BIM gene was recently shown to favor the production of non-apoptotic BIM isoforms, and t...

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Main Authors: Soh, Sheila Xinxuan, Lim, Joshua Yew Suang, Huang, John W. J., Jiang, Nan, Yeoh, Allen Eng Juh, Ong, S. Tiong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121131/
https://ncbi.nlm.nih.gov/pubmed/25090024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103435
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