Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

[Image: see text] The finding by scientists at Hoffmann-La Roche that cis-imidazolines could disrupt the protein–protein interaction between p53 and MDM2, thereby inducing apoptosis in cancer cells, raised considerable interest in this scaffold over the past decade. Initial routes to these small mol...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Vara, Brandon A., Mayasundari, Anand, Tellis, John C., Danneman, Michael W., Arredondo, Vanessa, Davis, Tyler A., Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120989/
https://ncbi.nlm.nih.gov/pubmed/25017623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo501003r
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge