Axitinib with or without dose titration for first-line metastatic renal-cell carcinoma: a randomised double-blind phase 2 trial

BACKGROUND: Population pharmacokinetic data suggest axitinib plasma exposure correlates with efficacy in metastatic renal-cell carcinoma. Axitinib dose titration might optimise exposure and improve outcomes. We prospectively assessed the efficacy and safety of axitinib dose titration in previously u...

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Detalhes bibliográficos
Main Authors: Rini, Brian I, Melichar, Bohuslav, Ueda, Takeshi, GrÜnwald, Viktor, Fishman, Mayer N, Arranz, José A, Bair, Angel H, Pithavala, Yazdi K, Andrews, Glen I, Pavlov, Dmitri, Kim, Sinil, Jonasch, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120767/
https://ncbi.nlm.nih.gov/pubmed/24140184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(13)70464-9
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