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Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables enantioselective formal synthesis of levomilnacipran()
Engineering enzymes capable of modes of activation unprecedented in nature will increase the range of industrially important molecules that can be synthesized through biocatalysis. However, low activity for a new function is often a limitation in adopting enzymes for preparative scale synthesis, rea...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4120663/ https://ncbi.nlm.nih.gov/pubmed/24802161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201402809 |
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