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Antagonizing c-Cbl Enhances EGFR-Dependent Corneal Epithelial Homeostasis
PURPOSE. In many cell types, the E3 ubiquitin ligase, c-Cbl, induces ligand-dependent ubiquitylation of the epidermal growth factor receptor (EGFR) and targets the receptor for lysosomal degradation. The goal of this study was to determine whether c-Cbl is a negative regulator of EGFR in the corneal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Association for Research in Vision and Ophthalmology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4120408/ https://ncbi.nlm.nih.gov/pubmed/24985478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14133 |
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