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Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU)

Monoamine neurotransmitter deficiency has been implicated in the etiology of neuropsychiatric symptoms associated with chronic hyperphenylalaninemia in phenylketonuria (PKU). Two proposed explanations for neurotransmitter deficiency in PKU include first, that chronically elevated blood L-phenylalani...

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Detalhes bibliográficos
Main Authors: Harding, Cary O., Winn, Shelley R., Gibson, K. Michael, Arning, Erland, Bottiglieri, Teodoro, Grompe, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119869/
https://ncbi.nlm.nih.gov/pubmed/24487571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-013-9675-2
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