EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells in vivo through Crosstalk with Akt and Regulates Stem Properties

Diffuse infiltrative invasion is a major cause for the dismal prognosis of glioblastoma (GBM), but the underlying mechanisms remain incompletely understood. Using human glioblastoma stem cells (GSCs) that recapitulate the invasive propensity of primary GBM, we find that EphA2 critically regulates GB...

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Detalhes bibliográficos
Main Authors: Miao, Hui, Gale, Nickolas W., Guo, Hong, Qian, Juan, Petty, Aaron, Kaspar, James, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George, Hambardzumyan, Dolores, Lathia, Justin D., Rich, Jeremy N., Lee, Jeongwu, Wang, Bingcheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119862/
https://ncbi.nlm.nih.gov/pubmed/24488013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.590
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