Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial

BACKGROUND: Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in combination with amitriptyline would be superior to amitriptyline alone in modifyi...

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Autors principals: de Zanette, Simone Azevedo, Vercelino, Rafael, Laste, Gabriela, Rozisky, Joanna Ripoll, Schwertner, André, Machado, Caroline Buzzatti, Xavier, Fernando, de Souza, Izabel Cristina Custódio, Deitos, Alicia, Torres, Iraci L S, Caumo, Wolnei
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119581/
https://ncbi.nlm.nih.gov/pubmed/25052847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-40
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