Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial

BACKGROUND: Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in combination with amitriptyline would be superior to amitriptyline alone in modifyi...

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Detalhes bibliográficos
Main Authors: de Zanette, Simone Azevedo, Vercelino, Rafael, Laste, Gabriela, Rozisky, Joanna Ripoll, Schwertner, André, Machado, Caroline Buzzatti, Xavier, Fernando, de Souza, Izabel Cristina Custódio, Deitos, Alicia, Torres, Iraci L S, Caumo, Wolnei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119581/
https://ncbi.nlm.nih.gov/pubmed/25052847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-40
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