Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer. Preclinical and clinical evidence links resistance to anti-estrogen drugs in breast cancer cells with the overexpression and/or activation of various pro-oncogenic tyrosine kinases. Disruption of circadia...

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Bibliographic Details
Main Authors: Dauchy, Robert T., Xiang, Shulin, Mao, Lulu, Brimer, Samantha, Wren, Melissa A., Yuan, Lin, Anbalagan, Muralidharan, Hauch, Adam, Frasch, Tripp, Rowan, Brian G., Blask, David E., Hill, Steven M.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119539/
https://ncbi.nlm.nih.gov/pubmed/25062775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3156
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