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Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle
Large-scale mitochondrial DNA (mtDNA) deletions are an important cause of mitochondrial disease, while somatic mtDNA deletions cause focal respiratory chain deficiency associated with ageing and neurodegenerative disorders. As mtDNA deletions only cause cellular pathology at high levels of mtDNA het...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119413/ https://ncbi.nlm.nih.gov/pubmed/24740879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu176 |
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