Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

As custom arrays are cheaper than generic GWAS arrays, larger sample size is achievable for gene discovery. Custom arrays can tag more variants through denser genotyping of SNPs at associated loci, but at the cost of losing genome-wide coverage. Balancing this trade-off is important for maximizing e...

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Autors principals: Chen, Guo-Bo, Lee, Sang Hong, Brion, Marie-Jo A., Montgomery, Grant W., Wray, Naomi R., Radford-Smith, Graham L., Visscher, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Association Studies Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119411/
https://ncbi.nlm.nih.gov/pubmed/24728037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu174
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