Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin

AIMS/HYPOTHESIS: Individuals carrying variants of the transcription factor 7-like 2 gene (TCF7L2) are at increased risk for type 2 diabetes. These metabolic genetic risk factors have been linked to diminished pancreatic islet-cell responsiveness to incretins, thus pharmacological interventions aimed...

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Bibliografiske detaljer
Main Authors: Zimdahl, Heike, Ittrich, Carina, Graefe-Mody, Ulrike, Boehm, Bernhard O., Mark, Michael, Woerle, Hans-Juergen, Dugi, Klaus A.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119242/
https://ncbi.nlm.nih.gov/pubmed/24906949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3276-y
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