Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition

The inhibitory effect of trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of ErbB2, is associated with its ability to induce ErbB2-Y1248 phosphorylation, and the status of phosphorylated ErbB2-Y1248 (ErbB2-pY1248) may correlate with the sensitivity of breast can...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dokmanovic, Milos, Wu, Yun, Shen, Yi, Chen, Jieqing, Hirsch, Dianne S, Wu, Wen Jin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2014
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119070/
https://ncbi.nlm.nih.gov/pubmed/24835103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29171
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