Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)--poly(L-lysine) carrier.

N-Acetylmuramyl-L-Ala-D-Glu-NH2 (muramyl dipeptide) and several of its derivatives are effective immunoactivators that can enhance nonspecific resistance to infection but can also elicit fever. In contrast, one of its stereoisomers, N-acetylmuramyl-D-Ala-D-Glu-NH2, is devoid of both these activities...

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Main Authors: Chedid, L, Parant, M, Parant, F, Audibert, F, Lefrancier, F, Choay, J, Sela, M
Format: Artigo
Jezik:Inglês
Izdano: 1979
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC411905/
https://ncbi.nlm.nih.gov/pubmed/293743
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