Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)--poly(L-lysine) carrier.

N-Acetylmuramyl-L-Ala-D-Glu-NH2 (muramyl dipeptide) and several of its derivatives are effective immunoactivators that can enhance nonspecific resistance to infection but can also elicit fever. In contrast, one of its stereoisomers, N-acetylmuramyl-D-Ala-D-Glu-NH2, is devoid of both these activities...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Chedid, L, Parant, M, Parant, F, Audibert, F, Lefrancier, F, Choay, J, Sela, M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1979
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411905/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/293743/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.12.6557
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