Creating stable stem regions for loop elongation in Fcabs — Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations

Fcabs (Fc antigen binding) are crystallizable fragments of IgG where the C-terminal structural loops of the CH3 domain are engineered for antigen binding. For the design of libraries it is beneficial to know positions that will permit loop elongation to increase the potential interaction surface wit...

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Hauptverfasser: Hasenhindl, Christoph, Lai, Balder, Delgado, Javier, Traxlmayr, Michael W., Stadlmayr, Gerhard, Rüker, Florian, Serrano, Luis, Oostenbrink, Chris, Obinger, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Pub. Co 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118681/
https://ncbi.nlm.nih.gov/pubmed/24792385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.04.020
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