Binding of cis- and trans-dichlorodiammineplatinum(II) to the nucleosome core
The binding of the antitumor drug cis-dichlorodiammineplatinum(II) and its inactive trans isomer with the nucleosome core particle has been investigated. Kinetic studies show that platinum binding increases with incubation time, from a few bound platinum atoms per nucleosome core in the first 0.5 hr...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1979
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411808/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/293706/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.12.6091 |
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