Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

During eukaryotic ribosome biogenesis, members of the conserved atypical serine/threonine protein kinase family, the RIO kinases (Rio1, Rio2 and Rio3) function in small ribosomal subunit biogenesis. Structural analysis of Rio2 indicated a role as a conformation-sensing ATPase rather than a kinase to...

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Hauptverfasser: Ferreira-Cerca, Sébastien, Kiburu, Irene, Thomson, Emma, LaRonde, Nicole, Hurt, Ed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117770/
https://ncbi.nlm.nih.gov/pubmed/24948609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku542
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