The AAA-ATPase Rea1 Drives Removal of Biogenesis Factors during Multiple Stages of 60S Ribosome Assembly

SUMMARY: The AAA(+)-ATPase Rea1 removes the ribosome biogenesis factor Rsa4 from pre-60S ribosomal subunits in the nucleoplasm to drive nuclear export of the subunit. To do this, Rea1 utilizes a MIDAS domain to bind a conserved motif in Rsa4. Here, we show that the Rea1 MIDAS domain binds another pr...

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Main Authors: Baßler, Jochen, Kallas, Martina, Pertschy, Brigitte, Ulbrich, Cornelia, Thoms, Matthias, Hurt, Ed
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372891/
https://ncbi.nlm.nih.gov/pubmed/20542003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.024
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