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Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens
A challenge for large-scale siRNA loss-of-function studies is the biological pleiotropy resulting from multiple modes of action of siRNA reagents. A major confounding feature of these reagents is the microRNA-like translational quelling resulting from short regions of oligonucleotide complementarity...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4117740/ https://ncbi.nlm.nih.gov/pubmed/24972830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku306 |
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