Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens

A challenge for large-scale siRNA loss-of-function studies is the biological pleiotropy resulting from multiple modes of action of siRNA reagents. A major confounding feature of these reagents is the microRNA-like translational quelling resulting from short regions of oligonucleotide complementarity...

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Main Authors: Zhong, Rui, Kim, Jimi, Kim, Hyun Seok, Kim, Minsoo, Lum, Lawrence, Levine, Beth, Xiao, Guanghua, White, Michael A., Xie, Yang
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117740/
https://ncbi.nlm.nih.gov/pubmed/24972830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku306
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