Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

One of the hallmarks of Alzheimer disease is the pathological aggregation of tau protein into paired helical filaments (PHFs) and neurofibrillary tangles. Here we describe the in vitro assembly of recombinant tau protein and constructs derived from it into PHFs. Though whole tau assembled poorly, co...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Schweers, O, Mandelkow, E M, Biernat, J, Mandelkow, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8463
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!