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Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.

Methotrexate (MTX) inhibition of the growth of mouse or human leukemia cells in culture was partially prevented by either thymidine (dThd) or hypoxanthine. 5-Fluoro-2'-deoxyuridine (FdUrd) also decreased the growth-inhibitory potency of MTX in the presence of small concentrations of 5-formyltet...

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Bibliografski detalji
Glavni autori: Moran, R G, Mulkins, M, Heidelberger, C
Format: Artigo
Jezik:Inglês
Izdano: 1979
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC411765/
https://ncbi.nlm.nih.gov/pubmed/160558
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