mRNA Decay Factor AUF1 Binds the Internal Ribosomal Entry Site of Enterovirus 71 and Inhibits Virus Replication

AU-rich element binding factor 1 (AUF1) has a role in the replication cycles of different viruses. Here we demonstrate that AUF1 binds the internal ribosome entry site (IRES) of enterovirus 71 (EV71) and negatively regulates IRES-dependent translation. During EV71 infection, AUF1 accumulates in the...

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Bibliographic Details
Main Authors: Lin, Jing-Yi, Li, Mei-Ling, Brewer, Gary
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117571/
https://ncbi.nlm.nih.gov/pubmed/25077793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103827
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