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Choice of Non-Inferiority (NI) Margins Does Not Protect against Degradation of Treatment Effects on an Average – An Observational Study of Registered and Published NI Trials
OBJECTIVE: NI margins have to be chosen appropriately to control the risk of degradation of treatment effects in non-inferiority (NI) trials. We aimed to study whether the current choice of NI margins protects sufficiently against a degradation of treatment effect on an average. STUDY DESIGN AND SET...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
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Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4117500/ https://ncbi.nlm.nih.gov/pubmed/25080093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103616 |
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