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Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes

BACKGROUND: The most important factor affecting metabolic excretion of compounds from the body is their half-life time. This provides an indication of compound stability of, for example, drug molecules. We report on our efforts to develop QSAR models for metabolic stability of compounds, based on in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zakharov, Alexey V, Peach, Megan L, Sitzmann, Markus, Filippov, Igor V, McCartney, Heather J, Smith, Layton H, Pugliese, Angelo, Nicklaus, Marc C
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117347/
https://ncbi.nlm.nih.gov/pubmed/23088274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.12.152
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