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Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions

Genomes assembled de novo from short reads are highly fragmented relative to the finished chromosomes of H. sapiens and key model organisms generated by the Human Genome Project. To address this, we need scalable, cost-effective methods enabling chromosome-scale contiguity. Here we show that genome-...

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Bibliografiske detaljer
Main Authors: Burton, Joshua N., Adey, Andrew, Patwardhan, Rupali P., Qiu, Ruolan, Kitzman, Jacob O., Shendure, Jay
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117202/
https://ncbi.nlm.nih.gov/pubmed/24185095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2727
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