SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders

The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg(−/−) mice show a premature expansion of polyclonal CD5(+)...

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Xehetasun bibliografikoak
Egile Nagusiak: Simonetti, Giorgia, Bertilaccio, Maria Teresa Sabrina, Rodriguez, Tania Veliz, Apollonio, Benedetta, Dagklis, Antonis, Rocchi, Martina, Innocenzi, Anna, Casola, Stefano, Winkler, Thomas H., Nitschke, Lars, Ponzoni, Maurilio, Caligaris-Cappio, Federico, Ghia, Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Ferrata Storti Foundation 2014
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116835/
https://ncbi.nlm.nih.gov/pubmed/24859880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.100230
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