SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders

The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg(−/−) mice show a premature expansion of polyclonal CD5(+)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Simonetti, Giorgia, Bertilaccio, Maria Teresa Sabrina, Rodriguez, Tania Veliz, Apollonio, Benedetta, Dagklis, Antonis, Rocchi, Martina, Innocenzi, Anna, Casola, Stefano, Winkler, Thomas H., Nitschke, Lars, Ponzoni, Maurilio, Caligaris-Cappio, Federico, Ghia, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116835/
https://ncbi.nlm.nih.gov/pubmed/24859880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.100230
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados