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SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders
The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg(−/−) mice show a premature expansion of polyclonal CD5(+)...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Ferrata Storti Foundation
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4116835/ https://ncbi.nlm.nih.gov/pubmed/24859880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.100230 |
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