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Protein synthesis in rabbit reticulocytes: characteristics of a postribosomal supernatant factor that reverses inhibition of protein synthesis in heme-deficient lysates and inhibition of ternary complex (Met-tRNAfMet.eIF-2.GTP) formation by heme-regulated inhibitor.

During heme deficiency in reticulocyte lysates, a translational inhibitor (heme-regulated inhibitor, HRI) that blocks polypeptide chain initiation is activated. HRI is a protein kinase that specifically phosphorylates the 38,000-dalton subunit of the Met-tRNAfMet binding factor, eIF-2. Phosphorylati...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ralston, R O, Das, A, Grace, M, Das, H, Gupta, N K
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411674/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/293657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.11.5490
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