Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice

The amyloid precursor protein (APP) and amyloid-β (Aβ) peptide play central roles in the pathology and etiology of Alzheimer’s disease. Amyloid-induced impairments in neurogenesis have been investigated in several transgenic mouse models but the mechanism of action remains to be conclusively demonst...

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Autores principales: Kanemoto, S., Griffin, J., Markham-Coultes, K., Aubert, I., Tandon, A., George-Hyslop, P.S., Fraser, P.E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116598/
https://ncbi.nlm.nih.gov/pubmed/24361736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.12.021
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