Concentration of Tacrolimus and Major Metabolites in Kidney Transplant Recipients as a Function of Diabetes Mellitus and Cytochrome P450 3A Gene Polymorphism

1. Disposition of tacrolimus and its major metabolites, 13-O-desmethyl tacrolimus (13-DMT) and 15-O-desmethyl tacrolimus (15-DMT), was evaluated in stable kidney transplant recipients in relation to diabetes mellitus and genetic polymorphism of cytochrome P450 (CYP) 3A. 2. Steady-state concentration...

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Main Authors: Chitnis, Shripad D., Ogasawara, Ken, Schniedewind, Björn, Gohh, Reginald Y., Christians, Uwe, Akhlaghi, Fatemeh
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116556/
https://ncbi.nlm.nih.gov/pubmed/23278282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2012.752118
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