Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.

[3H]Phencyclidine binds to synaptic membranes from rat brain in a saturable, reversible, and selective fashion, with a dissociation constant Kd of 0.25 microM and a maximal binding capacity of 2.4 pmol/mg of membrane protein--i.e., 250 pmol/g of brain. The binding activity is concentrated in synapto...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Vincent, J P, Kartalovski, B, Geneste, P, Kamenka, J M, Lazdunski, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1979
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411644/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/41247/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.9.4678
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