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Modulating Drug Resistance by Targeting BCRP/ABCG2 Using Retrovirus-Mediated RNA Interference

BACKGROUND: The BCRP/ABCG2 transporter, which mediates drug resistance in many types of cells, depends on energy provided by ATP hydrolysis. Here, a retrovirus encoding a shRNA targeting the ATP-binding domain of this protein was used to screen for highly efficient agents that could reverse drug res...

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Bibliografiske detaljer
Main Authors: Xie, Ni, Mou, Lisha, Yuan, Jianhui, Liu, Wenlan, Deng, Tingting, Li, Zigang, Jin, Yi, Hu, Zhangli
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116202/
https://ncbi.nlm.nih.gov/pubmed/25076217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103463
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