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Rational Modification of Estrogen Receptor by Combination of Computational and Experimental Analysis
In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor-ligand complexes with computational analysis, we wer...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4116177/ https://ncbi.nlm.nih.gov/pubmed/25075862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102658 |
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