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The Role of Parkin in Familial and Sporadic Parkinson’s Disease

Mutations in Parkin are the second most common known cause of Parkinson’s disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin’s E3 ligase activity is thought to play a pathogenic role in both...

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Hlavní autoři: Dawson, Ted M., Dawson, Valina L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115293/
https://ncbi.nlm.nih.gov/pubmed/20187240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.22798
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