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The Role of Parkin in Familial and Sporadic Parkinson’s Disease
Mutations in Parkin are the second most common known cause of Parkinson’s disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin’s E3 ligase activity is thought to play a pathogenic role in both...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115293/ https://ncbi.nlm.nih.gov/pubmed/20187240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.22798 |
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