A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Na(v)) channels (BgNa(v)1), whereas human Na(v) channels are insensitive. Here...

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Detalhes bibliográficos
Main Authors: Bende, Niraj S, Dziemborowicz, Slawomir, Mobli, Mehdi, Herzig, Volker, Gilchrist, John, Wagner, Jordan, Nicholson, Graham M, King, Glenn F, Bosmans, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115291/
https://ncbi.nlm.nih.gov/pubmed/25014760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5350
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