COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils

BACKGROUND: Eosinophilic airway inflammation is observed in 10-30% of COPD subjects. Whether increased eosinophils or impairment in their clearance by macrophages is associated with the severity and frequency of exacerbations is unknown. METHODS: We categorised 103 COPD subjects into 4 groups determ...

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Main Authors: Eltboli, Osama, Bafadhel, Mona, Hollins, Fay, Wright, Adam, Hargadon, Beverley, Kulkarni, Neeta, Brightling, Christopher
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115214/
https://ncbi.nlm.nih.gov/pubmed/25007795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-14-112
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