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Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: Outsourcing a key task
The superoxide-generating NADPH oxidase of phagocytes consists of the membrane-associated cytochrome b(558) (a heterodimer of Nox2 and p22(phox)) and 4 cytosolic components: p47(phox), p67(phox), p40(phox), and the small GTPase, Rac, in complex with RhoGDI. Superoxide is produced by the NADPH-driven...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4114928/ https://ncbi.nlm.nih.gov/pubmed/24598074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.27952 |
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