Unanchored K48-linked poly-ubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase mediated antiviral response

Type-I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of hundreds of IFN-I stimulated genes (ISGs). The full breadth of ISG induction demands activation of a number of cellular factors including the IκB ki...

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Autors principals: Rajsbaum, Ricardo, Versteeg, Gijs A., Schmid, Sonja, Maestre, Ana M., Belicha-Villanueva, Alan, Martínez-Romero, Carles, Patel, Jenish R., Morrison, Juliet, Pisanelli, Giuseppe, Miorin, Lisa, Laurent-Rolle, Maudry, Moulton, Hong M., Stein, David A., Fernandez-Sesma, Ana, tenOever, Benjamin R., García-Sastre, Adolfo
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114019/
https://ncbi.nlm.nih.gov/pubmed/24882218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.018
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