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The Medicinal Chemistry of Imidazotetrazine Prodrugs
Temozolomide (TMZ) is the standard first line treatment for malignant glioma, reaching “blockbuster” status in 2010, yet it remains the only drug in its class. The main constraints on the clinical effectiveness of TMZ therapy are its requirement for active DNA mismatch repair (MMR) proteins for acti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4113733/ https://ncbi.nlm.nih.gov/pubmed/25014631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph7070797 |
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