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mTOR Signaling from Cellular Senescence to Organismal Aging
The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanism...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
JKL International LLC
2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4113516/ https://ncbi.nlm.nih.gov/pubmed/25110610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2014.0500263 |
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