Drug-nucleic acid interactions: conformational flexibility at the intercalation site.
The conformational features of the intercalation site in polynucleotides were examined. We found that, for all the crystal structures of drug-dinucleoside complexes studied thus far, two torsion angles differ from those found in A RNA (phi and chi) and that alternate sugar puckering is not a prerequ...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1978
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411350/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/273246/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.2.828 |
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