Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

The conformational features of the intercalation site in polynucleotides were examined. We found that, for all the crystal structures of drug-dinucleoside complexes studied thus far, two torsion angles differ from those found in A RNA (phi and chi) and that alternate sugar puckering is not a prerequ...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Berman, H M, Neidle, S, Stodola, R K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1978
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411350/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/273246/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.2.828
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